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ACTEMRA: The First Biologic to Inhibit IL-6 Signaling - Proposed Mechanism of Action
Proposed Effects of IL-6 Signaling Inhibition on Pharmacodynamic Parameters

The mechanism of action has been elucidated in preclinical models and by PK/PD data. Its clinical significance is unknown.
IL-6 is a key contributor to inflammation and has been shown to inhibit IL-6-mediated signaling1

IL-6 is a pleiotropic pro-inflammatory cytokine

ACTEMRA is a humanized monoclonal antibody that targets the IL-6 receptor
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